产品货号：
Z35788
中文名称：
PPM1D抗体
英文名称：
Anti-PPM1D Antibody (Clone#OTI3A7)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PPM1D Antibody (Clone#OTI3A7) |
| 指标别名 | protein phosphatase;Mg2+/Mn2+ dependent 1D;IDDGIP;JDVS;PP2C-DELTA;WIP1;PPM1D |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | PPM1D |
| 克隆号 | OTI3A7 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG1 |
| 免疫原 | Human recombinant protein fragment corresponding to amino acids 1-375 of human PPM1D (NP_003611) produced in E.coli. |
| 实际分子量 | 66.5KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.It is mapped to 17q23.2.The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases.PP2C family members are known to be negative regulators of cell stress response pathways.The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses.While being induced by tumor suppressor protein TP53/p53,this phosphatase negatively regulates the activity of p38 MAP kinase,MAPK/p38,through which it reduces the phosphorylation of p53,and in turn suppresses p53-mediated transcription and apoptosis.This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis.This gene is located in a chromosomal region known to be amplified in breast cancer.The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors,which suggests a role of this gene in cancer development. |
| Uniprot ID | O15297 |
| 基因名全称 | protein phosphatase,Mg2+/Mn2+ dependent 1D |
| 蛋白名全称 | Protein phosphatase 1D |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：PPM1D抗体，PPM1D单抗，Anti-PPM1D Antibody (Clone#OTI3A7)